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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
25.76
Human Site:
S284
Identified Species:
40.48
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
S284
R
V
T
S
G
G
V
S
E
S
P
S
G
F
S
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
S284
R
V
T
S
G
G
V
S
E
S
P
S
G
F
S
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
S284
R
V
T
S
G
G
V
S
E
S
P
S
G
F
S
Dog
Lupus familis
XP_852191
460
52810
S268
R
V
T
S
G
G
V
S
E
S
P
S
G
F
S
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
S284
R
A
T
S
G
G
M
S
E
S
S
S
G
F
S
Rat
Rattus norvegicus
Q91ZN7
476
54410
S284
R
A
T
S
G
G
M
S
E
S
S
S
G
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
A284
R
A
S
S
G
G
L
A
D
S
P
G
G
F
G
Chicken
Gallus gallus
Q8AYC9
476
53830
T284
R
V
S
S
G
G
V
T
E
S
P
G
A
L
P
Frog
Xenopus laevis
Q6DE87
474
53957
S283
S
R
V
I
S
G
G
S
S
D
S
S
V
L
C
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
I235
G
I
T
P
A
A
K
I
Q
R
A
D
S
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
A296
S
Y
D
L
V
D
S
A
A
A
L
E
I
C
S
Honey Bee
Apis mellifera
XP_623436
467
53927
E282
E
G
Y
I
R
P
D
E
T
D
S
R
Q
I
I
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
A304
N
G
R
P
L
K
R
A
R
N
N
D
E
N
I
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
M284
S
S
P
N
T
G
S
M
K
R
V
C
T
G
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
I245
S
P
G
A
K
N
L
I
V
R
I
L
D
P
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
100
N.A.
80
80
N.A.
53.3
60
20
6.6
N.A.
6.6
0
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
80
73.3
20
20
N.A.
20
0
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
0
7
7
7
0
20
7
7
7
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
7
7
% C
% Asp:
0
0
7
0
0
7
7
0
7
14
0
14
7
0
0
% D
% Glu:
7
0
0
0
0
0
0
7
47
0
0
7
7
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
47
0
% F
% Gly:
7
14
7
0
54
67
7
0
0
0
0
14
47
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
14
0
0
0
14
0
0
7
0
7
7
14
% I
% Lys:
0
0
0
0
7
7
7
0
7
0
0
0
0
0
0
% K
% Leu:
0
0
0
7
7
0
14
0
0
0
7
7
0
14
7
% L
% Met:
0
0
0
0
0
0
14
7
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
7
0
7
0
0
0
7
7
0
0
7
14
% N
% Pro:
0
7
7
14
0
7
0
0
0
0
40
0
0
7
7
% P
% Gln:
0
0
0
0
0
0
0
0
7
0
0
0
7
0
0
% Q
% Arg:
54
7
7
0
7
0
7
0
7
20
0
7
0
0
0
% R
% Ser:
27
7
14
54
7
0
14
47
7
54
27
47
7
0
47
% S
% Thr:
0
0
47
0
7
0
0
7
7
0
0
0
7
0
0
% T
% Val:
0
34
7
0
7
0
34
0
7
0
7
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _